Invited Speaker Australian & New Zealand Society of Magnetic Resonance Conference 2017

Clinical translation of dissolution Dynamic Nuclear Polarization (#29)

Jan Henrik Ardenkjær-Larsen 1 2
  1. Department of Electrical Engineering, Center for Magnetic Resonance, Technical University of Denmark, 2800 Kgs, Lyngby, Denmark
  2. Department of Electrical Engineering, Center for Magnetic Resonance, Technical University of Denmark, 2800 Kgs, Lyngby, Denmark

Hyperpolarization by dissolution Dynamic Nuclear Polarization (dDNP) is a versatile method for making solutions of strongly polarized nuclear spins in small molecules. The method has enabled a range of in vivo and in vitro applications that otherwise would not be possible. In particular, clinical imaging is now a reality with hyperpolarized 13C-pyruvate. In this work, we will present recent polarizer developments aiming towards higher nuclear spin polarization. Initial results with a new polarizer design will be discussed. The polarizer is based on a dry magnet generating a magnetic field up to 10T and equipped with a re-condensing variable temperature insert (VTI) reaching a base temperature of less than 1.3K. More than 70% 13C polarization is obtained for pyruvate in less than an hour. It is critical for the clinical translation of hyperpolarization by the dDNP that the technology is simple and robust, and deliver sterile solutions with appropriate quality assurance on demand. In our pursuit to accelerate the image acquisition and reach the ultimate sensitivity, we have developed cryogenic receiver arrays for 13C at 3T. Another critical aspect to the success of hyperpolarized MRI. Preliminary data with an 8-channel head coil will be presented demonstrating a two-fold increase in SNR over a commercial array coil for 13C head imaging. Due to the short relaxation time of nuclear spins in solution, hyperpolarized MRI and NMR require the immediate proximity of the polarizer to the spectrometer or scanner. However, recent work with labile radicals has demonstrated that solid samples with long nuclear polarization time can be retrieved from the polarizer, stored and transported to a more distant point-of-use. We present recent DNP work with radicals generated with UV light, that can be quenched by elevating the temperature of the solid sample. These radicals have been characterized for both 1H and 13C polarization.